JNJ 10191584 maleate ( JNJ 10191584 maleate salt; VUF6002 maleate )

Catalog No. M27640 CAS No. 869497-75-6

histamine H4 receptor silent antagonist

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	203	Get Quote
25MG	447	Get Quote
50MG	651	Get Quote
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Biological Information

Product Name

JNJ 10191584 maleate
Note

Research use only, not for human use.
Brief Description

histamine H4 receptor silent antagonist
Description

histamine H4 receptor silent antagonist(In Vitro):JNJ 10191584 maleate shows 540-fold selectivity to H4 receptor(Ki = 14.1 μM).(In Vivo):In spared nerve injury mice, JNJ 10191584 maleate (10 μg/μL; intra locus coeruleus administration) abolishes VUF-induced anti-allodynic effect and prevents the anti-allodynic effect of VUF 8430. JNJ 10191584 maleate (6 μg/mouse; intrathecal administration) prevents VUF 8430-induced anti-allodynic effect.
Synonyms

JNJ 10191584 maleate salt; VUF6002 maleate
Pathway

Others
Target

Other Targets
Recptor

DNA/RNA Synthesis
Research Area

——
Indication

——

Chemical Information

CAS Number

869497-75-6
Formula Weight

394.8
Molecular Formula

C17H19ClN4O5
Purity

>98% (HPLC)
Solubility

——
SMILES

OC(=O)\C=C\C(O)=O.CN1CCN(CC1)C(=O)c1nc2ccc(Cl)cc2[nH]1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Hassan AE, et al. 6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases. Bioorg Chem. 2016 Apr;65:9-16.

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