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JNJ 10191584 maleate

CAS No. 869497-75-6

JNJ 10191584 maleate ( JNJ 10191584 maleate salt; VUF6002 maleate )

Catalog No. M27640 CAS No. 869497-75-6

histamine H4 receptor silent antagonist

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 203 Get Quote
25MG 447 Get Quote
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Biological Information

  • Product Name
    JNJ 10191584 maleate
  • Note
    Research use only, not for human use.
  • Brief Description
    histamine H4 receptor silent antagonist
  • Description
    histamine H4 receptor silent antagonist(In Vitro):JNJ 10191584 maleate shows 540-fold selectivity to H4 receptor(Ki = 14.1 μM).(In Vivo):In spared nerve injury mice, JNJ 10191584 maleate (10 μg/μL; intra locus coeruleus administration) abolishes VUF-induced anti-allodynic effect and prevents the anti-allodynic effect of VUF 8430. JNJ 10191584 maleate (6 μg/mouse; intrathecal administration) prevents VUF 8430-induced anti-allodynic effect.
  • Synonyms
    JNJ 10191584 maleate salt; VUF6002 maleate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    869497-75-6
  • Formula Weight
    394.8
  • Molecular Formula
    C17H19ClN4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC(=O)\C=C\C(O)=O.CN1CCN(CC1)C(=O)c1nc2ccc(Cl)cc2[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hassan AE, et al. 6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases. Bioorg Chem. 2016 Apr;65:9-16.
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